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On a lung perfusion scan, a wedge-shaped, PLEURAL-BASED perfusion defect (broad base at the pleural surface, apex pointing toward the hilum) is identified. The ventilation scan is normal in the same region. This WEDGE-SHAPED peripheral mismatch is the classic scintigraphic appearance of:
D. Pulmonary embolism — embolic occlusion of a segmental or subsegmental pulmonary artery
The classic scintigraphic appearance of PE on perfusion scan is a WEDGE-SHAPED (or 'pleural-based') perfusion defect, where the broad base is at the pleural surface and the narrow apex points toward the hilum — following the anatomic distribution of a pulmonary artery branch. This shape reflects the vascular anatomy of a segmental or subsegmental artery territory. The corresponding ventilation scan is NORMAL (ventilation-perfusion mismatch). Multiple such wedge-shaped defects in different lung zones constitute a high probability pattern. Pleural effusion causes a uniformly decreased peripheral perfusion without a discrete wedge shape.
Lung Perfusion Projections: Why Lateral Views Matter
High-Probability V/Q Scan: Mismatched Defects
Matched V/Q Defects: Low Probability for PE
Normal Lung Perfusion Scan and Pulmonary Embolism
Reducing MAA Particles in Pulmonary Hypertension
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