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IMAGE INTERPRETATION · BRAIN IMAGING

Normal Brain Perfusion SPECT with Tc-99m HMPAO

Tc-99m HMPAO or ECD brain perfusion SPECT — normal distribution
Tc-99m HMPAO or ECD brain perfusion SPECT — normal distribution

CC BY-SA 3.0 · Dr Bruno Di Muzio / Radiopaedia / Wikimedia Commons · source file

Question

This brain perfusion SPECT shows the usual distribution pattern: highest uptake in the grey matter (cortex, basal ganglia, cerebellum) and lower uptake in white matter. Which radiopharmaceutical is most commonly used for brain perfusion SPECT?

  1. ATc-99m HMPAO (hexamethylpropyleneamine oxime)
  2. BTc-99m MDP
  3. CTc-99m DTPA
  4. DI-123 ioflupane (DaTSCAN)
Show the answer and explanation

A. Tc-99m HMPAO (hexamethylpropyleneamine oxime)

Tc-99m HMPAO (Ceretec) and Tc-99m ECD (Neurolite) are the radiopharmaceuticals used for brain perfusion SPECT. They are lipophilic agents that cross the blood-brain barrier and are retained in neurons proportional to cerebral blood flow. HMPAO was the first widely used agent. Tc-99m MDP is used for bone scans. Tc-99m DTPA is used for renal studies and blood-brain barrier integrity scans. DaTSCAN images dopamine transporters, not perfusion.

More brain imaging images

Brain perfusion SPECT — transaxial, coronal, sagittal, and temporal slices showing regional cerebral blood flow pattern in dementiaAlzheimer’s Disease on Brain Perfusion SPECT DaTSCAN (I-123 ioflupane) SPECT — normal striatal uptakeParkinson’s Disease on DaTscan: Loss of the Comma Shape Brain perfusion SPECT — frontal lobe hypoperfusion patternFrontotemporal Dementia on Brain Perfusion SPECT Brain scan statics at 5, 10, and 20 minutes showing absence of cerebral perfusion — only scalp/skull activity visibleBrain Death Scan: Absent Cerebral Perfusion Brain perfusion SPECT — comparison of ictal and interictal statesIctal SPECT: Hyperperfusion at the Seizure Focus I-123 DaTSCAN SPECT (transverse slices) showing asymmetrically reduced striatal dopamine transporter uptakeDementia with Lewy Bodies on DaTscan
← DaTscan (I-123 Ioflupane): What It EvaluatesAlzheimer’s Disease on Brain Perfusion SPECT →

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