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IMAGE INTERPRETATION · INFECTION AND INFLAMMATION

In-111 Oxine WBC Scan: Agent and Timing

In-111 oxine WBC scan: whole-body anterior and posterior views with abdominal spot images
In-111 oxine WBC scan: whole-body anterior and posterior views with abdominal spot images

Provided clinical image

Question

This whole-body scan shows anterior and posterior views along with abdominal spot images. Based on the biodistribution pattern — prominent uptake in the liver, spleen, and abnormal lung activity — which radiopharmaceutical was most likely used and what is its standard imaging schedule?

  1. ATc-99m HMPAO-labeled WBCs; images are obtained at 1, 4, and 24 hours after reinjection, with delayed imaging used to improve specificity for chronic infection
  2. BIn-111 oxine-labeled WBCs; images are typically obtained at 24 hours after reinjection, with an optional earlier image at 4 hours post-reinjection
  3. CGa-67 citrate; the radiopharmaceutical is injected directly without any in vitro cell labeling, and images are acquired at 24, 48, and 72 hours
  4. DTc-99m sulfur colloid; images are obtained 30–60 minutes after reinjection to assess white blood cell distribution in the liver, spleen, and bone marrow
Show the answer and explanation

B. In-111 oxine-labeled WBCs; images are typically obtained at 24 hours after reinjection, with an optional earlier image at 4 hours post-reinjection

In-111 oxine (indium-111 oxyquinoline) is used to label white blood cells in vitro: the patient's blood is drawn, WBCs are isolated, incubated with In-111 oxine, then reinjected. Images are typically acquired at 24 hours post-reinjection to allow adequate WBC migration to sites of infection, with an optional 4-hour early image. The physical half-life of In-111 (67.3 hours) makes 24-hour delayed imaging practical.

More infection and inflammation images

In-111 oxine WBC scan: whole-body anterior and posterior views with abdominal spot imagesAbnormal Lung Uptake on In-111 WBC Scan FDG PET/CT — whole body for unknown source of infectionFDG PET/CT for Fever of Unknown Origin Ga-67 whole-body scan (anterior and posterior) showing bilateral symmetric hilar and mediastinal uptake — positive study for sarcoidosisSarcoidosis on Gallium Scan: Panda and Lambda Signs Ga-67 citrate whole-body scan performed for evaluation of sarcoidosis — anterior and posterior projectionsGallium-67 Imaging Times for Sarcoidosis Ga-67 citrate whole-body scan: posterior and anterior viewsGa-67 Citrate Whole-Body Scan: Agent and Timing Ga-67 citrate whole-body scan: posterior and anterior viewsAbnormal Bilateral Lung Uptake on Gallium Scan
← Abnormal Bilateral Lung Uptake on Gallium ScanAbnormal Lung Uptake on In-111 WBC Scan →

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