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These cardiac SPECT images show an apparent inferior wall perfusion defect on the non-attenuation-corrected images (top) that is no longer visible on the attenuation-corrected images (bottom). What is the most likely cause of the apparent inferior wall defect on the non-corrected images?
A. Diaphragmatic attenuation artifact
Diaphragmatic attenuation is the most common cause of apparent inferior wall defects on non-corrected cardiac SPECT, particularly in male patients. The diaphragm overlies and attenuates photons from the inferior wall of the left ventricle, creating a false-positive perfusion defect. Attenuation correction (using CT or transmission scan data) compensates for this, and the defect disappears — confirming it as artifact rather than true ischemia or infarction.
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